De Uptown Riders Motorcycle Club is een motorclub in Liberty City. De gang bestaat veelal uit Afro-Amerikanen en de leden rijden op Japanse sportmotors. De gang is gebaseerd in Northwood en North Holland. Gekende leden zijn:

De gang verschijnt alleen in The Lost and Damned, en niet in Grand Theft Auto IV of The Ballad of Gay Tony.

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